From behind the register of a petrol station to spam in your email, you've probably seen men's health products promising stronger erections. Many of these are knockoffs or illegal and can interact with other medications, leading to dangerous side effects.

One safe and legal treatment for erectile dysfunction is Kamagra 100, which contains the same active ingredient as Viagra. This article will delve into the medication's mechanism of action and why it's effective.

Sildenafil inhibits PDE5 enzymes.

Sildenafil, sold as Viagra and other ED drugs like Levitra (Vardenafil), Cialis (Tadalafil), and Stendra (Avanafil), inhibits the action of PDE5 enzymes. These enzymes break down a chemical called cyclic guanosine monophosphate, or cGMP. This causes blood vessels in the penis to relax, allowing more blood flow to the area and leading to an erection when you're sexually aroused.

PDE5 enzymes are present in the brain, lungs, heart, kidney, bladder, prostate, urethra, and penis. The enzymes are made of two identical monomers with a regulatory domain in the amino-terminal region and a catalytic site in the carboxyl-terminal region. The catalytic domain has four subsites: the M site, the Q pocket, the H pocket, and the L region (or lid region) [1, 2].

The binding of inhibitors to PDE5 results in a conformational change in the enzyme that changes its ability to degrade cGMP. Vardenafil and sildenafil bind to the PDE5 catalytic site at the M site, the Q pocket, and the H pocket with high affinity.

It increases blood flow to the penis.

Sildenafil stops the activity of phosphodiesterase type 5 enzymes, increasing blood flow to the penis and allowing you to have a firm erection. This effect only happens if you are sexually aroused, so Viagra won’t give you an involuntary erection if you take it without sexual stimulation.

Erectile dysfunction (ED) occurs because of poor blood flow to the penis, and a good erection depends on a carefully choreographed series of events that begin with arousal signals from your brain. The erection also requires the dilating and stiffening of certain blood vessels in the area that’s called the corpora cavernosa. Nitric oxide is released in these chambers during sexual stimulation, and it increases levels of cyclic guanosine monophosphate (cGMP). This chemical opens and widens the blood vessels in the corpora cavernosa. 

Kamagra Polo Chewable 100mgis a pill that contains sildenafil, but it can also be found as an oral jelly that you place in your mouth to dissolve and be absorbed. The oral jelly form is claimed to work faster than the pill because it allows for a more immediate response.

It increases erectile function.

Sildenafil inhibits the enzyme that controls the muscles, managing blood flow to the erectile tissues of the penis, so it makes it easier to get and keep an erection. It also helps prevent premature ejaculation during sexual activity. As a result, it increases sexual performance and can even be used to treat some forms of ED in men who are not able to get an erection at all (off-label use).

The active ingredient in Kamagra is sildenafil citrate, which works in the same way as Viagra. However, the manufacturer claims that Kamagra contains other ingredients in addition to sildenafil citrate. These other ingredients are supposed to create a gel-like texture when the tablet is mixed with water. However, because this product is not regulated or licensed in the UK, it is difficult to verify the truth of these claims.

Taking prescription-only medicines without first consulting your doctor could put your health at risk, so it’s best to only buy Kamagra from a reputable, legal website registered with the Care Quality Commission. There are also many different medications that can interact dangerously with ED medicine, including drugs for heart disease and high blood pressure, so it’s essential to consult your doctor before you take anything, even herbal remedies.

To work, Kamagra needs to be taken at least 30 minutes or an hour before sexual stimulation begins. It’s also important to note that consuming high-fat foods can reduce the medication’s effectiveness, so you should avoid eating these foods while on this medication.